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High liver & kidney enzymes. Loss of appetite & PROIN issues

SkylarS

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May 6, 2025
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Cali, 4.5 yrs old, female 2. Spayed 3. Redbone Coonhound mutt rescue 4. 85lbs 5. What's their BEAM: behavior - 7, energy - 6, appetite - 5, mood - 6, Diet - 2.

Vaccination history - gets yearly lyme vaccines, had rabies shot, "allergy" shots.

Primary problem is Cali's high enzymes in her liver and kidney. She has been drinking tons of water and barely eating. Our vet recommended we take her off PROIN until we see the ultrasound (on May 14th). Once we took her off PROIN, it was constant urination when laying down/sleeping. Our Vet said the amount of water she is drinking is over riding the Proin. One day was constant urination from the beginning of the day, throughout the night. We removed all carpets to help with cleanup. We asked if she could be put back on PROIN because her quality of life that full week off of it was not good. It was constant baths and cleanup of urine and she seemed really run down. We put her back on PROIN for this week and the volume of her accidents has gone from puddles to dribbles. She appears to have more energy and seems happier (not sure if this is a side effect of being back on PROIN).
This began shortly after she was prescribed CARPROFEN for a limp she had for possible dysplasia. The vet prescribed it for two weeks and after the two weeks was when her panting got excessive, stopped eating her kibble and started urinating. Blood tests were done and the high liver and kidney enzymes were found. She has since been prescribed Mirtazapine and Maropitant nausea and appetite increaser.

The condition has not really changed or does not change based on exercise, type of food, etc.

10. She had blood tests done and is getting a ultrasound done on May 14

We are trying to switch over to a homecooked diet and have tried to put together some recipes based on some books, articles, etc but am not sure portions, supplements, etc that can help with healing liver and kidney.

Her other main health concern aside from the enzymes is her incontinence which we would love to get her off PROIN but do not know where to start because when she was off of it, it was constant urination 24/7. We are wondering if any other options will be as effective.

We just joined this community and cannot wait to learn more and hopefully help our pup Cali out more naturally. (Apologies if this post is too long?) We are just unsure of where to start and the information is overwhelming. Thank you!!

@Dr. Jeff , @Dr. Christina
 

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  • Idexx-Report-274034716-29191-25-04-30-7-35.pdf
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Welcome to HA! Skylar!

Thanks for making your first post about Cali. 😍 :dog2:

How old was she when you adopted her?

Do you know anything about her "backstory" before you rescued her?
Diet - 2.
Does that mean that you'd rank the quality of her food as a 2?

Oh, I just saw the time (I have a HA! call in 2 minutes and then will come back to your post.
 
Hi @Dr. Jeff ,

We rescued her at 10 weeks. She lived outdoors in a pen in Arkansas before we adopted her. We were feeding her prescription food from our vet, Royal Canin and switched to Kirkland brand (which we rated the 2), which we understand now just how bad it is for dogs and we are now on our journey of switching to fresh, which we do not know where to start!
 
This began shortly after she was prescribed CARPROFEN
I bet you already know this, but there's a possible trigger (NOT cause) for the incontinence.
The vet prescribed it for two weeks and after the two weeks was when her panting got excessive, stopped eating her kibble and started urinating. Blood tests were done and the high liver and kidney enzymes were found.
Has she had any other recent (past year) blood work other than the 3/19/21 results?

BTW-Thank you for sharing the Idexx results. I got quite and education on the true value of diagnostic tests. In short, it appears that the class of molecules called "cystatins" are produced by many different sources in the body and just show that individual cells are "sick".


Like all, dis-eases (sickness due to imbalance), this too can pass.

I wouldn't worry too much about her cystatin B and liver value elevation. IMHO they are merely a secondary effect of her totality.

The framework and strategies we will share here at HA! should help.

Working 1:1 with a vet homeopath might also be useful.

Feel free to post any questions, set up a 15 minute Holistic Medical Decision Making call or 2 hour initial evaluation call (Kim at [email protected] can share the new client appointment link).
 
Thanks for your rapid reply Skylar. They came in just as I was posting my previous post...
we do not know where to start!
Yes, I hear 'ya! Many people come to HA! knowing that there must be another way (or more to know) and not knowing what is reliable info, where to start, etc.

You're in the right place. At HA! we focus on helping members reduce overwhelm.

We do that through a specific framework that goes beyond what we learn as conventional veterinarians.
 
As Dr. Jeff said, your biggest first step is to begin right now to get started with a homeopathic veterinarian. When the correct match is made, ALL the symptoms can resolve. While waiting for the appointment, there is much you can do to make Cali feel better. A lot of it is your state of mind, meditating, being positive, etc. go to the list of past webinars and listen to/or watch the ones on energy medicine, indigenous health, laughter yoga, etc. Most of Jan and Feb for the last few years will help you be less stressed, which will help Cali.

Possible homeopathic vets who can work virtually (where do you live?) include Dr. Jeff, Dr. Judith Herman, Dr. Todd Cooney, Dr. Adriana Sagrera. (www.theAVH.org has contact info). There may be some great general holistic vets near you who can help soothe the issues. Read this article.
 
Hi @SkylarS, welcome!
It's completely understandable to feel overwhelmed as you navigate Cali’s health challenges—you're not alone in this.

A great place to begin is by slowly working through our 101 course. It offers a clear, step-by-step roadmap and can help break things down into manageable actions.

I’d also recommend scheduling a 15-minute call—it’s a great way to prioritize next steps and get grounded in where to begin.

You’ve got this, and we’re here to support you.
 
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